Pentobarbitone, but not propofol, produces pre-emptive analgesia in the rat formalin model
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چکیده
منابع مشابه
Pentobarbitone, but not propofol, produces pre-emptive analgesia in the rat formalin model.
Injection of formalin into the hindpaw of a rat induces a biphasic response in pain-related behaviours, such that C-fibre activation during phase 1 triggers a state of central sensitization characterized by a longer lasting phase 2. As the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) may participate in processing of nociceptive inputs, we hypothesized that pentobarbitone and propo...
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pain has been dominated by an outdated conceptualization of pain.1 Pain is viewed as the end-product of a passive transmission system that faithfully transmits a peripheral signal to the spinal cord and on up to a pain centre in the brain. This view has led to an approach of managing postoperative pain that does not provide adequate control of pain, in part, because it focuses on treating the p...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1994
ISSN: 0007-0912
DOI: 10.1093/bja/72.6.662